According to the ACG Guidelines, improving Quality of Life (QoL) is a key goal of therapy in active ulcerative colitis.1
QoL measured by the Inflammatory Bowel Disease Questionnaire (IBDQ)*
- 32 questions with graded responses (1 to 7 points) examining four aspects of patients' lives
- Scores range from 32 to 224 (higher scores are associated with better QoL)
- Increase in total IBDQ score >20 points is associated with clinically significant improvement3
* Inflammatory Bowel Disease Questionnaire (IBDQ) is copyrighted by McMaster University.
References: 1. Kornbluth A et al. Am J Gastroenterol. 2004;99:1371-1385. 2. Sninsky CA et al. Gastroenterology & Hepatology. 2008;4(suppl 4):1-10. 3. Higgins PDR et al. Gut. 2005;54:782-788.
According to the ACG Guidelines, improving Quality of Life (QoL) is a key goal of therapy in active ulcerative colitis.1
References: 1. Kornbluth A et al. Am J Gastroenterol. 2004;99:1371-1385. 2. Data on file, Procter & Gamble Pharmaceuticals, Inc. 3. Sninsky CA et al. Gastroenterology & Hepatology. 2008;4(suppl 4):1-10.
Selected Safety Information
Asacol is indicated for the treatment of mildly to moderately active UC (the indicated dosage is two 400 mg tablets tid for 6 weeks) and for the maintenance of remission of UC (the indicated dosage is 1.6 g/day in divided doses).In pivotal clinical studies of mildly to moderately active UC, the most frequent adverse events reported for Asacol and placebo, respectively, were headache (35% vs 36%), abdominal pain (18% vs 14%), and eructation (16% vs 15%); for the maintenance of remission of UC, the most frequent adverse events were headache (50% vs 50%), rhinitis (42% vs 36%) , and diarrhea (35% vs 50%).
Asacol is contraindicated in patients with hypersensitivity to salicylates. Caution should be exercised when using Asacol in patients with known renal dysfunction or history of renal disease. It is recommended that all patients have an evaluation of renal function prior to initiation of Asacol tablets and periodically while on Asacol therapy. Serious adverse events may occur with Asacol.
Please see accompanying full prescribing information by clicking the link above.
