Ulcerative Colitis Treatment

How Asacol Can Work For You

Asacol (mesalamine) delayed-release tablets are designed with a special outer coating that targets the delivery of the medication to the colon where it is needed.
  • Once swallowed, this coating allows the whole tablet to travel in one piece through the stomach until it reaches the end of the small intestine and the beginning of the colon.
  • At the beginning of the colon, the tablet's special coating begins to crack/dissolve and release the active ingredient, mesalamine, to work throughout the entire colon.
  • The active ingredient acts throughout the colon to help reduce inflammation of the inner lining of the colon and rectum.
When taking Asacol, be sure to swallow your tablets whole – do not break or chew them. Chewing breaks the special outer coating.

In clinical studies, a small percentage of people (2-3%) reported passage in the stool of what appeared to be whole tablets, fragments of tablets or tablet shells. If this occurs repeatedly, contact your doctor.

Who Should Not Take Asacol

You should not take Asacol if you are allergic to Asacol or to salicylates such as aspirin. Tell your doctor if you have kidney problems or a history of kidney disease. It is recommended that all people have their kidney function tested prior to starting Asacol tablets and periodically while on Asacol therapy. Serious side effects may occur.

If you have questions about taking Asacol, please talk to your doctor and see the accompanying product information by clicking on the link above.


Asacol (mesalamine) delayed-release tablets, available only by prescription, are indicated to treat mild to moderate flare-ups of ulcerative colitis and maintain remission of ulcerative colitis. Asacol is generally well tolerated. In studies of flare-ups, some people taking Asacol reported headache, abdominal pain, general pain, rash, upset stomach, and worsening of colitis symptoms. In a six month maintenance study, some people reported headache, runny nose, general pain, sore throat, infection, and nervousness. You should not take Asacol if you are allergic to Asacol or to salicylates such as aspirin. Tell your doctor if you have kidney problems or a history of kidney disease. It is recommended that all people have their kidney function tested prior to starting Asacol tablets and periodically while on Asacol therapy. Serious side effects may occur. If you have questions about taking Asacol, please talk to your doctor.
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